Jimm,
Have heard a lot of negatives and some positives on nickle brass. Personally I wouldn't use it unless I had to. That being said, I just bought 100 nickle cases for the 7mm Mag I'm building. Why, so no one gets em confused and shoves a round in one of my .264 Win Mags! My wife, my son, and I go to the range every other weekend, and I just wanted to simplify things by letting my wife have the bright shiny rounds! The metal will be harder to trim & debur, they will likely be tougher on your dies, but if you're doing things the right way, I doubt you'll see any severe consequences any time soon. Clean your dies after each job, and you should not have any major problems.