I changed from a 5.5~22 to a 8~32 NXS on my 338 LM. Then changed back to a 5.5~22. The up side is more magnification that is great and really helps with long range groups. But the down side is, as mentioned, loss of 35 moa, plus the increased mirage, and huge loss of field of view.
I could have lived with all of them other than the loss of moa simply by turning it down some. But even zeroed at 300 with a custom milled base that gave me all 65 moa up I didnt like running out at a mile. I dont shoot a ton past a mile but, I find myself doing it more often these days. And the 22x will get me there.
Jeff