I've shot and reloaded 22-250 and the Ackley version for 35 years.
This past year I bought a Tikka 595 Master Class with 1:14 twist x 23" factory barrel. NXS 8-32 optics
Berger bullets are my favorite and I chose a 52 gr. bullet in a MATCH (small hollowpoint with a flat base.)
I started averaging accuracy of 1" at 100 yards using Varget, 760, Imr4895, RL15 and some others. Next session I seated that bullet 4 thou from the rifling all the groups shrunk in half.
Shooting through a chrony I found that Ramshot BigGame provided the highest average velocity and very best 5 shot groups.
Caution: You'll have to start lower and work up on powder quantity.
My pet load is:
Nosler Custom brass with 41.o BigGame, Berger 52 Match, seated 4 thou from rifling, avg. velocity 3903 fps
There is minimal VISUAL pressure sign on the brass or primer but it must be on the hot side since my brass is reloaded only 5x before it's discarded.
I did a 1/4" group at 200 yards
Varget provided single digit ES and SD but the veloicty was only 3650 fps