.
1) I would do it quick with a powder thrower and if it was within a grain (sometimes 2) of the load...
2) Does bullet play a large role in a reload? can one bullet have a significantly higher accuracy than the other?
3) Do I need to buy all the 300gr bullets for the Lapua and all the 140gr bullets for my Creedmoor and dial in what bullet my gun likes best?
4) Or will proper seating depth and powder charge be the main factors in the accuracy of my load?
5) Also both guns do have twist rates suitable for the weights I would like to use
1) Nothing wrong with volume, but don't let people who don't understand the difference tell you it's about weight. Other than a VMD, I haven't weighed, nor check for a weight, in over a decade. I shoot a couple rifles to a mile, hasn't caused me any disadvantage.
2) Unless you give a lot more detail, or can razzle us with your marksmanship; we can't answer that. What is "significantly different" to you? Are you prepared to actually do load work, or just ask for a load online? Are you shooting for 1-hole groups at a mile, or are you going for minute of barn at 300?
Not saying any answer is wrong, but there isn't an easy answer without any of that. If you want to talk jacket tolerances and run-out, then not significantly different. If you want to talk dispersion at distance, then the BC difference matters.
3) That's up to you. Personally, and I'm sure this will ****-off someone with a favorite brand tattooed on their ***; No. 85% of the shooters out there are just too uninvolved/lazy to realize it. Again there is nuance, but it is truly rare to buy a match bullet that won't shoot. Some will be easier to make shoot a little better a little quicker, but something else is wrong if "it won't shoot".
4) Proper charge mostly. Despite claims otherwise, I find most bullets to be stunningly immune to seating depth. That is a fine tuning bit, not a make or break.
5) If this was truly meant as a statement, then let's clear the air on this subject.
Bullet "weight" doesn't matter to stability, bullet LENGTH matters. Not all 300gr bullets are the same length.
See lengths at this JBM site:
JBM - Calculations - Stability
Look them up from the menu on the left. You can either use that calculator, or Berger's to get an idea of stability. I personally like Berger's as it is a little more specific about BC with the extra rotation, but lacks any warning about maximum RPM. Though to be fair, that's mostly an issue in varmint cartridges.
Cheers