I have a 300 Weatherby
I have shot CX
I have not put the 2 together.
CX start pressure is seems much higher than Barnes. I did some back to back comparisons in my 300 WSM but again, not in the 300 Wby. There seems to be some changes since I last used them, grooves that probably reduce start pressure.
That said as a caveat and having run your 2 powder choices through QuickLOAD and looking in all the online and electronic reloading manuals because my paper manuals are still boxed.
IMO LRT is just too slow.
N565 can do it but it seems slow. Usable but slow. Of course there are legal weirdness's about telling you a load. Sorry. I'll listen to advise and opinions on that as my fear comes from being in Kommiefornia where you can be sued for sneezing and put in jail for mis-gendering.
If I could get to my stuff I'd throw some loads in 300 Wby and see if QuickLOAD is real or full of BS on the N565 idea.
Limited but maybe helpful.