As long as your aren't over 175-200 lbs I think you will be OK. I would only be concerned about a close shoulder shot. As the velocity slows downrange, the penetration should be adequate. Even if you don't pass thru, dumping 4000 lbs of energy into that small of an animal is bound to be devastating.
I will say that I've only been able to get around 1 MOA (+ or - 1/4 MOA) accuracy out of my SAKO 75 w/them. This week I plan to work up some loads with some heavier bullets, including some of the famed Wildcat bullets, to see if I can't get a little better accuracy.
Try RL 22, it gave me the best velocity (3940 fps) and accuracy. IMR 7828 was real dissapointment on velocity. Only got about 3600 fps out of it.