.....If you look in my gun closet (not in the safe but on the shelf), you'll see only pismuckle green boxes of Sierra pills, well, thats a white lie, you'll also see some red (Hornady boxes of 223-55 grain VMax's.
250 Sierra's are my go to in 338 Lapua (same propellant or Varget), but H1000 is as good IMO. GK or MK, depending on the scenario.
165 Sierra's for my 308 Savage in GK's or MK's depending.
My only issue with Sierra's is the meplat. It's touchy. You have to be careful when seating and you can't bang them around in your pocket or an ammo box. I actually custom machined a seater arbor to fit my Gold Medal Seat die so I don't bugger the meplat.
It's certainly all about shot placement. A **** poor shot with a high tech pill is a **** poor shot nonetheless. A lousy shot about guarantees a trip over hill and dale (read mountains and valleys) chasing a leaking animal..... Not fun.
I guess we could all go hunting with Barrett 50's but then who wants to carry one???