The only round I have found that shoots well thru my Fierce 28 Nosler is the factory 160 AB. I want to shoot a heavier bullet if I could for more energy out past 800 yards to nock down an elk. So I'm going to do my first ladder test using RE33. My question is, If I find the powder charge node the gun likes and I change bullets (possibly heavier) down the road will I have to do the ladder test again? Also if I find the gun for example shoot likes 160 AB at 3100 fps will a different powder pushing the same bullets at the same speed still be in the node? I figure if I change powders I'll have to do a new ladder test. With the limited availability of powders these days who knows what will be avaliable. I may need to change powders according to avaliabilty not necessarily on what the gun likes.