The BIG 6's can be a little tough on throats, but hey, so are other cartridges we enjoy. In my opinion, barrels are disposable items like race car tires. Over the decades, I have settled down to the 6mmAI as my largest 6 with a few 243/AI's thrown in for fun. In the 6AI, I can run the 105's @ 3,200 with ease, and at my hunting altitudes, they still have 2,000fps and 900ft/lbs or so @ 900 yards. For deer and antelope sized game, I find it to be sufficient, and I haven't lost an animal due to bullet failure. Granted my longest game kill with that round hasn't been over 800.
A friend of mine used his 6-284 to set a few older 1,000yd BR records, and with regular cleaning, he had little issues with that round. Maybe one day I may try another larger 6 with a faster twist for the 115's or so, but for now, the 6AI or similar has me happy.