A balistic program like Barnes's balistic program will give you the info. If you give me your caliber, bullet weight, muzzel velocity and zero range. Then the different altitudes I could give you an idea how much it changes your down range trajectory.
I just played around with one of my loads and at 975 yards a change from sea level at 60 degrees to 15,000 feet and 10 degrees changed the drop from 163.45" to 123.52" Thats a little over 3 feet difference. That is a pretty extreme change. I really doubt you ever hunt or shoot high enough to ever have to adjust for it. A strictly barometric change would have an even less affect. A 5000 foot change in elevation changed impact by 17" at 975 yards.
So, I guess if you're really stretching it out there then you may have to adjust a bit for it. Shoot me your info for your situation and I will run it across my program.