By no means am I an expert on ballistics, just relaying info I've read else where that made sense to me. I know the 7mm loads I shoot have a recommended minimum velocity where they have reliable performance, I would venture to say it'd be the same deal with varmint type bullets. Like the other have said practice with whatever load you plan hunting with and let the yote tell you how far is too far. I'm by no means telling you to use a live animal for test media but, read more info and how others have had the load perform at whatever distance you plan to shoot. If you read a few forums that support what you're trying to achieve give it a shot, if you have good results go for it. The only way to know with absolute certainty is to try. I remember growing up people telling me my 243win wasn't good past 300yd, with studying the tables and practice I have no issues shooting to 500yd with the loads I run.