First, being a Ruger 10/22 owner, I can tell you to stay away from a Ruger 10/22 if accuracy is your goal. It takes more money to get them up to out-of-the-box CZ 452 accuracy than a CZ 452 will cost you. I use mine with 30-round magazines to machine gun prairie dogs uising cheap ammo when they are bunched up; otherwise, it's a fairly worthless rifle to me.
I never could stand the Savage style of bolt. CZ 452 is closer to Mauser style. CZ 452 is almost same size, balance, style and weight as CZ 527, so it's a good trainer for the more expensive centerfire. I chose a CZ452 in .22LR and a CZ 527 in .223 Rem. Good 2-rifle combo at dogtown. CZ 452 takes out the close PD's, with Stingers or Velocitors, both very accurate in a CZ 452.
The other possibility is the Ruger 77/22 and M77 combination. My brother-in-law went that route, with a M77 MkII in .22-250 to match his 77/22 in .22LR. Handling is very similar to one another, just like in the CZ's mentioned above.
If you have deep pockets, a Sako Quad rimfire and Sako 85 centerfire combo would be hard to beat at any price. If I could afford it, that is probably what I would own.
Another good combo would be a Kimber rimfire and a Kimber centerfire rifle.
I believe your rimfire should be similar in handling to your centerfire, if you want to use the rimfire to be a training tool to keep you in handling practice for the centerfire. CZ rimfires are available with the single set trigger option. Maybe other combos are better than the CZ, but none I have found for the same price.
Too bad Remington and Winchester have decided not to compete against CZ, Sako, Ruger and Savage and have dropped their bolt action rimfires. A CZ 452 or Ruger 77/22 would go well with any Mauser type of centerfire, and both are well worth their price and available everywhere.
The CZ 455 and Sako Quad are especially versatile rifles with quick change barrels, if your needs change at different times of the year.
For 2011, CZ has dropped the price on the CZ 455 to $395 MSRP. They are an even better buy than in the past.
The more you shoot a CZ, the better it gets. I've put about 2000 rounds through my CZ 452 this summer at dogtown, and it just keeps working slicker and shooting straighter. Same goes for my CZ 527.