I have a 10 twist in mine and it does not like 100gn bullets, most likely due to the high velocity of the round. My two best loads were with RL-25 and 115 gn Nosler Bal tips and 110gn Accubonds with Ramshot magnum. The bal tips were very accurate but did not perform well. At 3550 fps, they were varmint bullets and did not penetrate well. I am getting as good of accuracy with the Accubonds. I also switched away from the RL-25, as it is a stick powder and is prone to powder bridging in the 257 stw duue to the large capacity/small caliber. The ball powders do not have the same problem. My best load is: 76.2gns Ramshot Magnum, Fed 210M, 110gn Accubond (3500fps). This is near max in my gun and you should prob start around 73.0gns. My max RL-25 load was 78.0gns. This was a warm load, but again, I experienced some weird pressure spikes and attribute it to powder bridging, so I cannot recommend this load. Good luck.