Depends on the BC used, Sierra uses G1, so, using multiple BCs helps make ballistics fit better. Using G7 BC, generally gets more accurate drop/velocity/drift data without using multiple BCs......has to do with bullet shape, G1 doesn't work as well with modern boat tail and VLD bullets as the G7 does....there's more to it, but I don't have my books in front of me to go into it more.
Check out Bryan Litz's book for a real good look at BC and other things