Bore guides dont restrict throat cleaning. They center and guide the rod into the throat and bore. A general cleaning with a good copper and powder remover should get your throat clean. I use Bore Tech eliminator and Wipeout. I usually start with Bore Tech to get most of the fouling out and then finish up with one or two soakings with Wipeout which is a spray-in foam cleaner. It will get your bore and throat totally free of copper and remove most of the powder. If I want to remove all the powder, I found that Montana Extreme Copper Cream is good at that. The directions i got from a product tech was to put the cream on a patch and run it to the muzzle but not all the way out, pull it back and then push and pull it back and forth a few times and repeat with more patches until the patches come out white. There are some other good powder removers as well.
For chambers I use a larege cal brush and wrap a large patch around it and twist it in the chamber now and then.
Hope that helps,
Mark