Do a test by volume. Set the measure, run 20 to settle the power. Get the dropped weight of the old powder. Empty. Add new lot with same measure setting, run 20 to settle the powder. Compare both weights using the same volume. Any difference?
By volume,IMR4198, (not H) there can be as much as 1.1 gr difference in weight. 18.5 gr vs 19.6 gr. with the measure at the same setting. This was older Canada vs Australia. Mix if the same lot number. Other wise, work up a new loading.
https://apps.dtic.mil/docs/citations/ADA572333
"To consider the likely pressure variations, consider that QuickLoad V3.6 predicts a muzzle
velocity of 3174 ft/s and a peak pressure of 54371 psi for 79 grains of H4831 using the 155
grain AMAX in the .300 Win Mag. This is very close to the 3177.5 ft/s velocity that results from
averaging the measurements over all six lots of powder. However, compensating for possible
lot to lot velocity variations requires a range of powder charges spanning from 77.5 to 80.5
grains of powder and a range of pressures from 51063 psi to 57910 psi. It is possible that a
load showing no signs of pressure with one lot of powder might not be safe with another lot of
powder. At their web site, Hodgdon recommends working up new loads when the lot number
of any component is changed, and it is evident that this includes a new lot of Hodgdon."