Norm, I have both and reload for them. They use the same Berger 115 gr but different powders and primers. I checked a lot of shops and found Weatherby factory ammo for less than $30 a box, pulled bullets or shot them to have the brass. They both shoot very accurate, but I have to go with the .257 Wby for the extra slam it has at longer ranges. Feel confident using the Wby on mule deer and the 25-06 on smaller game like Coues deer. Don't know your distance needs there, but out west the shot distances are usually quite a reach. Once the cost of brass is absorbed the difference in loading the two is negligible. Weigh your options and get what you will be happy with. Good luck