I have taken a couple of coyotes, a few deer and multiple antelope with that combination. Closest shot was 90 yards on an antelope. Hit right behind the shoulder it hit the dirt stood up and then fell over again. 50 cent size exit on that one. Farthest was 660 yards on antelope. DRT silver dollar sized exit. only time i have not got an exit was on a large doe mule deer this year at 440. The bullet his shoulder blade ribs and more ribs and destroyed everything in between. I have been very happy with the 105 amax but i dont think It would be a good choice on anything bigger than mule deer. Not the best for coyotes if you are saving pelts either.