I've seen more deer fall to a dose of h414 and a 150 out of an '06 than any other load in that caliber. I bet I've fired over 1,000 rounds of that combo... I've since had three or four more '06 rifles (I think I'm on my 5th... is it bad when you have a time remembering how many rifles in a caliber you have had??) and this rifle seems to like 4895 more than h414, but I have a keg of 4320 for my 375 that may get tried in the 06 also. It is an old mil. load powder for the '06 so it will work fine.