I will throw 2 cents in this ring, having hunted and then guided antelope in northern New Mexico ( Wagon Mound and Raton) you have a lot of gun for them. Much more than needed.
Yes a lot of people shoot 30 caliber out there, because they have to.
6MM, 6.5 or 7mm is what we recommended to do the job
These are LIGHT skinned: Light boned animals built for speed.
Put the spot and stalk on them, When guiding out there, we were required to put our hunters within 150 yards.
Get good optics, good boots and some snake guards.
Best of luck
M.Bird