I used nothing but RL 22 and the 160 accubond for a few years. Accuracy was great, but velocity topped out at 2820 in my factory Rem 700 with a 24" barrel.
Was about to order a custom barrel when a friend of mine suggested trying RL 25, and i'm sure glad i did.
3000 fps and 3/4" 3-shot groups at 200 yards!! Not exactly benchrest accuracy, but pretty good for a stock hunting rifle. Was able to go up to 3050 fps safely, but groups started to open up noticeably.