AS Fred Moore of SHARP SHOOTERS SAVAGE said, the 75 gr A-Max was designed as a long range competetion bullet to shoot through bowling balls at 1000 yds in the 22-243 AI.
I have only shot through a bowling ball at 850 yds, and as he said, it pokes right through without moving the ball. But blows up live game at any distance.
My best today is 1151yds witnessed by myself and two other Varmint Hunter Club members in ND. We used lazer range finder with quad and person as backstop for ranging.
I use 1-8 twist but the 1-9 works good too. In a 1-12 twist they tumble at 75 yds.
Best cal. I have ever used.........I sight in at 400 yds for zero and the drop at 1000 yds with max load is 16". So I just aim and shoot for the most part until scoping out distant target on 20 power or more, then I just hold over.
If you dog hunt you know the one dog over and two dogs high routine! well with the 22-243 AI just hold up or down and you hit out to 600-700 yds before the wind becomes a problem. The 22-250 need 2-4 dogs windage.