While I have had cases when I can achieve the same accuracy/ES duplicating the velocity with a different powder and the same bullet/seating depth, it can't be assumed that this will always be the case, particularly taking ES into account. I have experienced differences in accuracy/ES at the same MV with not only different powders, but different primers as well. I believe burn rate/pressure ramp of a particular powder can be a contributor to not only accuracy, but ES as well. In testing one of my 6.5x284's using the same 140 HVLD/seating depth, and 210M primer between Retumbo and R26. I was able to generate 2980FPS with each powder using 57gr of Retumbo vs. 54gr of R26. While the 200 yard, 5 shot groups were .2MOA for the Retumbo load, and .5MOA for the R26, which was very promising, the ES of the R26 load was 28FPS compared to <10FPS with Retumbo, a showstopper for 1000 yard LRH. I expect that I could tighten up the R26, and potentially even end up with a higher velocity load(+50-100FPS) with some further work, but as I have mentioned in other posts, I'm not sure the view is worth the climb given my current LRH results.