When my rifle was finished .Gunsmith told me to start at lowest load and work up in .3 gr increments. I started out at 41grs of Re#22 pushing Sierra 107 gr (,lowest load felt like I was firing a flintlock) Now I have settled on 53.5 grs of Re#22 for a velocity of 3,450. Do you have Sierra's 5th Edition ? They have some great starting loads for this cartridge. I posted on 24 hr Campfire and another shooter responded with his experience of burning up his bbl using Ramshot Magnum.............. Later this year a new powder is supposed to be coming out called Re#33 it might be interesting to try.