I use a Weatherby Mk V, Vortex 2.5-10x, 223, 53gr V-max out to 350 yards. I zero at 100. I use the 1st hash mark to 235yds. Just above the 2nd hash mark to 350 yards.
I sold my 22-250 due to wind deflection out beyond 350 yards and built a Remington 700 SA, in 243AI, 1-10 twist Krieger barrel with muzzle break, Jewel Trigger set at 1.5#, shooting 85gr Sierra Match Kings at 3100fps. Sight: Nightforce 4.5-15x50 NSX. Sighted in at 100 yards. I've killed a bobcat at 300 yards holding the 1st hash mark on it's shoulder (POA/POI). Coyotes 470 with the 4th hash mark and 670 yards holding with the 8th hash mark. I use a kestrel wind meter and hold off with the windage hash marks.
Strongly recommend the 243/243AI. A 1-8 twist allows you to shoot the 107gr match bullets. But I'm more than happy with my setup.
The 243 allows you to hunt deer, hogs and antelope as well.
Gonzo
SEMPER FIDELIS