I get a kick out of hearing all the warnings about the Colt and that you should not load it over 1000 fps even in the Blackhawk and Redhawks from Ruger. This is simply bunk. I do not mean to offend but again, this is silly.
If your loading in a strong modern firearm, especially one from Ruger, the 45 Colt will EASILY top anything the 44 Magnum chambering can be loaded with. In fact it will drive a 25 gr heavier bullet to the same velocity as any 44 magnum loads.
I have several Colt handguns. My current bear protection handgun for back country hunting here in Montana where Grizzlies are becoming a serious problem is a 4 5/8" Ruger stainless steel Blackhawk and she is loaded with the 360 gr. Cast Performance hard case bullets loaded to 1200 fps. I have shot thousands of these rounds through this handgun and they perform great and are WELL within the safe working limits of this handgun design.
The worries about the Colt are from the old days when there were balloon head cases around. These did not have solid case heads and were very weak. Those have not been in production for nearly 100 years. Modern 45 Colt brass is made to the same standards as the 44 Mag and even 454 Cassul standards of strength.
In fact, I developed loads for a customers custom Bowen 45 Colt Blackhawk that was fitted with a 5 shot custom cylinder. Using Federal 45 Colt brass, I was able to load the 300 gr Speer Unicore SP to 1600 fps, right there with the 454 and brass would easily fall out of the cylinder.
The 330 gr bullet weights could easily be driven to +1200 fps and with careful loading in the big Ruger handguns you can eaily push 1300 fps with this bullet weight. If they are swaged or softer case bullets with no gas check you will run into barrel leading issues but other then that there is no reason to limit their velocity to under 1000 fps.
I would totally agree that big bore handguns do not need alot of velocity to perform well on game but the best performance I have seen in 41, 44, 45, 475 and 50 cal in handguns has been that 1100-1200 fps range. Best accuracy, best penetration and best terminal slap.
I would also recommend you get some of the Cast Performance bullets as they are specifically designed for big game hunting and you will get much better results from these. If you want an expanding bullet, your much better off with a jacketed bullet. The new 250 gr Speer Gold dot is amazing in the Colt even loaded to magnum colt velocities. I perfer the Cast performance hard case because they generrally shoot better and cost less and will penetrate MUCH deeper. Their huge flat nose design also displaces much more vital tissue then even expanding bullets as they move alot more tissue over their entire penetration path, just not at the expansion point of the HP bullets.
Hope this helps.
Let us know what handgun your shooting these loads in. That will determine where you should load them to.