I've shot just about every bullet made from my 45-70 and have used all the usual powders. At the end of the day it's hard to beat 4198 (H or IMR) regardless of bullet weight. An all around effective bullet that shoots well, expands adequately, penetrates more than enough and is reasonably priced would be the Speer 400gr JFN.
You could load them up to any reasonable velocity and expect good results on game. I normally shoot them at 1,700 ft/sec and have take many black bears with that bullet, including the bear in my avatar which was taken in Newfoundland.