The primary disadvantage of the 50 over the 40 is more weight. The weight of a lens goes up with about the cube of it's diameter. Recoil puts more strain on mounts holding heaver scopes, also with lighter rifle and heavier cartridges. You also have to carry the scope and rifle. Maybe you just shoot close to your truck and weight doesn't matter or maybe you climb mountains. You didn't say, but it should be considered in making your choice,
Looking through several hundred yards of sun warmed atmosphere the 40 will give a bit more jittery images. The 50 will be a bit more blurry but that difference is small. Neither is diffraction limited at magnifications used for hunting or long range target shooting. Image resolution is nearly always atmosphere limited.
An advantage of a 50 is to give a few more minutes of light at sunrise and sunset or better resolution in low light (moonlight) where you can barely see in color.
In my opinion a more important consideration in picking a scope is the contrast when looking into shadows near sunset. Poor contrast comes from off axis sunlight scattering off the scope's optical and internal opaque surfaces, including the eye and the eyepiece. That's what really separates well designed rifle and spotting scope from junk. Scope specifications generally don't give a good comparison, nor does advertising hype.
I prefer to compare scopes by looking at a hill with trees with the sun a few degrees above your line of sight, as you would find about a half hour before sunset or after sunrise on a clear day. It should be around the distance you expect to shoot. Scattered light will "wash out" the image. Sunshades can help as does wearing a hat which keeps direct sunlight off of the eyepiece and your eye.
Rifles scopes should be optimized for aiming the rifle. For finding game binoculars give much better results with their large field of view. They can be light weight too.