I shot a 375 H&H a lot, back in the late 90's, both Mod 700s and one Mod 70. I only used the 300SBT in the Mod 700 and it shot very well right at 2600fps also with WW760 ( I tried Boddington's recipe) However, at 200yds the it was still "too soft" on a cow elk, lots of damage. I was pressed fror time for an African PG hunt, and the then available Winchester factory load ( 270 Failsafe) shot very well, we killed lots of game with it in several 375's, Winchester, Mod 700 and a Whitworth Express....but nothing even close to long range. Upon return, for grins, I had that Mod 700 reamed to the 375 Weatherby. (I liked reading about Hal Waughs "Big Nan") man oh man, what a screamer with the 270X. In fireformed Win brass I got some wonderful velocities. I got in a bind, wanted a hunt for aoudad and traded the rifle to my outfitter on the hunt. However, in my limited experience, I saw great advantage in the 375 Bee. I'm sure the 375 RUM and ilk are great too, but that Bee was very simple to load for. I can see the advantage of a heavy bullet for bucking the wind and terminal "thump", I am not sure a standard weight hunting rifle will do what a specialized LRH set up properly can do. But a CZ550 is pretty heavy, so may work just fine, I don't know. I am still impressed with how well the old H&H case design has held up in this modern world of new powders/bullets/primers/scopes. Its an old Honey.