Respectfully Benchracer, I disagree. There have been bullets 350-385 grains available in .375 for many years. The Barnes original I can personally say will work in 1-12. Their newer TSX (?) is the current listing, the Rhino 385 are also reportedly work 1-12, Woodleigh also has 350 soft points and FMJ.
The niche market for .375 heavyweights for "standard" cartridges and twist is occupied, and not all that strong. Most in this category are rightfully happy with 300 Partitions etc. for Brown Bear, and a possible African trip.
Granted, a couple of bullets exist in long range form as well, but these shooters may be small in number, but they shoot a bunch of bullets.
Set the goal of outperforming the .338's, then do it, and bullets will sell. Market the guys who replace barrels anyway.
Admittedly, my opinion on this most likely places me squarely in the minority. In my personal experiments, so far, I have found bullets like the Sierra 350g Matchking to stabilize in a 12 twist without a problem. The issue with that bullet, the only high bc standard construction bullet currently in existence, is that it takes AT LEAST a RUM class cartridge to push it to a useful velocity. There are very few of those in existence. There just aren't enough large cased .375's in existence to form a viable market. That is why the 350g SMK is a niche bullet for a niche market.
OTOH, the majority of .375's made are in cases smaller than the RUM. That class of cartridges is capable of running with the RUM/Lapua class .338's with the right bullets. The only bullets that offer that ability now are expensive custom bullets. I would submit that there are far more of the smaller cased .375's in existence than there are .338 RUM's and Lapuas. If the bullet manufacturers would offer bullets with decent bc's that are suited to an initial MV of 2700 to 2800 fps and a 12 twist, it would totally change the character of the H&H/Ruger class .375's. That class of .375's can offer flexibility that the RUM and Lapua .338's simply cannot match. Moreover, the .375's can do it in actions that are more common and less expensive than those required to accommodate the Lapua class cartridges (and some of those needed to house a RUM). Based on what I suspect are the relative numbers of .375's out there vs RUM/Lapua class .338's, I believe the right .375 bullet, properly marketed, is capable of eclipsing sales of comparable .338 bullets very quickly.
If the insistence is on high bc 350-400+ grain .375 bullets, the .375's will be doomed to a perpetual niche market. There simply will not be enough sales of bullets that require custom rifles to be built to launch them to entice anyone to manufacture them. The ONLY reason the Sierra 350 SMK exists in the first place had to do with development for a military contract. Conversely, the smaller cased .375's are sitting on top of a well of untapped ballistic potential. That same potential would benefit those shooting the larger cased .375's too.
The larger cased .338's and .375's quickly become specialized tools, which automatically limits their appeal to a small group of people. Availability of high bc bullets, of conventional construction, at reasonable cost, and that will work in the H&H class cartridges and up, offers the potential to have a legitimate long range rifle, a dangerous game rifle, and a conventional big game rifle all in a package that can be had for $800-$1000 for the rifle. I believe that is the key to making high bc .375 bullets commercially viable and, thus, more widely available. Going the heavy route in .375 is the surest way I can think of to stay mired in a niche market.
Ultimately, if the high bc .375 bullets being made require a custom rifle, then the barrier for entry into that part of the sport has been set so high that very few people will cross it. That is the same factor that held the .338's back for so long. My overall point is that, for the desired technological development to take place in .375 at anything faster than a glacial pace, the barriers to entry have to be lowered. Making products that can and will offer advantages in commonly available .375's will do that. Making specialized bullets for specialized rifles will not.