I've used the 64-grain Power Point bullet to shoot a bunch of deer, and it works great. Pennsylvania used to have a doe season that was separate from the general buck season, and I had gotten tired of blowing both shoulders all to bits on 100-pound does with the .308. So, I loaded up the .22-250 with enough IMR-4350 to get them moving at around 3300 fps, and went to town with it. Minimal meat damage was the goal, and that's how it worked out. They also fell down very suddenly, with mostly broadside lung shots. All bullets exited, with exit wounds about the size of a nickel. I never shot any through the shoulders, so I don't know how well that bullet works when you hit bones. ( It did break both shoulders and exit on all the Montana coyotes I shot with that load, if that tells you what you want to know about that.)
In your cartridge they are going to go a lot faster than I was shooting them, so they may expand more violently. You could saw one in half and see if they are still making them with a heavy jacket. I did that years ago, and the jacket in the shank of the bullet was more than twice as thick as that of the 55-grain soft points we were using at the time to shoot woodchucks.
With your fast-twist barrel, you could probably use much longer & heavier bullets. Somebody suggested 90-grain bullets, and that's the direction I would lean - especially in a large capacity cartridge that will generate good velocities. There's a 90-grain Fusion bullet, if you like bonded lead-core bullets, and the monolithic bullets are available in .224 diameter in weights up to about 70 grains if that is your preference. Also, you already know the rifle likes the 75-grain Scirrocco, which ought to put a serious hurt on those Montana prairie goats you mentioned. Watch the temperature sensitivity on the RL 22 powder - it gets hot out there on the prairie sometimes during antelope season. As for the bit about leaving the brass long, you might do a chamber cast with Cerrosafe to see just how long the neck of your particular chamber is, and trim them appropriately for that length. Good luck, and have fun.