Caleb:
I have the rifle that you intend to build. I started with a Remington VS in 22-250. I had the action trued, the crown recut and the barrel rechambered. The barrel is a stock remington varmint contour 1 in 12 twist. Under three hundred yards this is the most accurate rifle that I own. If I shoot greater than .5 moa with this rifle I know I am having a bad day. The barrel shows a preference for both 52g and 60g bergers. The smallest group it i have gotten with it is less than .043 MOA (that is not a typo). It was one hole at 320 yards. I wish I could claim that it was pure skill but I know that it was luck, and I will likely never repeat a group like that again. Those are all of the positives. Now for the negatives: first, I do not get anywhere near the published velocities for this load. Most of my chronograph data suggests that I am getting maximum "normal" 22-250 velocities. Second fireforming brass is a major Pain in the backside, that also eats up barrel life. I ended up restocking this gun with a B&C A2 medalist, with CDI bottom metal, so that I could shoot it in tactical competitions. The very steep sholder looks really cool, but makes bullet feeding a bit rougher than a standard bottle neck round. Barrel life is also an issue to consider. I have over 500 rounds through mine and have not seen any erosion in accuracy yet. If I were to do this again, I would set the rifle up to shoot the much heavier 22 cal rounds, which means that I would want a 1-8 or faster twist. With 77 - 80 grain bullets, you will still be going over 3000fps, which would be great for tactical matches, and longer range targets. However, the hyper velocity light bullets aren't bad if your game is watching small furry targets explode.
Hope this helps
John