I am currently putting together a 22-250. Proof cf barrel 1-8 twist. Primary use is varmints and maybe culling does with 70 gr Hammer Hunter. My philosophy is if I need a larger bullet than this setup will stabilize, about 70 gr, then I need to move up in caliber. If shooting 105s in the 22 CM with a 1-7 twist it is going to be blistering fast and hot on the barrel when shooting a 55 gr varmin load. Get a 6 CM or a 243 for the 80-110 weight bullets and you have ratcheted up to the next level.
Just my 2 cents worth.