I might start a ****ing match here but I would never consider taking a shot at a deer size target with any of these rounds at 400 yards let alone 500 to 600 yards.
There are just far better rounds for the job that do not generate much more recoil.
Coyotes, you bet, all day long, hammer away.
Pronghorns, sure with heavy bullets in fast twists, still 500 yards is a poke with the 22 cals of any size on this size game.
Why not get into something like a fast twist 6mm-06. Built one last spring for a guy on a 28" Kreiger 1-9" barrel that is shooting the 105 gr A-Max bullets into the .3's at 3500 fps.
For taking a deer at 500 yards, this is where I would consider the minimum level of power, far above any 22 cal or 243 Win.
This is also one of the easiest wildcats to load for, run a 25-06 brass thoughthe full length sizer and load and shoot, there you go. Feed like silk with its shallow shoulder, is very accurate and has the power and trajectory for takin gshots at game ou to 500 yards or a bit beyond.
To be honest, your 25-06 is a better round then all of them if you use the proper bullet with the a stout load.
Good Shooting!!
Kirby Allen(50)