The beautiful thing about "big bore" cartridges is, high velocity is not needed…..in fact can/will be detrimental to penetration. That lower velocity equates to a much more comfortable/tolerable handgun to shoot.
A heavy, lets say 300 grains or more, bullet at 1000 mv will likely "out penetrate" the same bullet pushed at a higher velocity. Read some of John Linebaugh's findings, you may be surprised!
In a handgun, higher velocities will help flatten trajectories for longer shots…..but are actually "counterproductive" at point blank range! I love the S&W 460 XVR, which is too heavy/large for backpack use, if I were to carry mine solely for defensive purposes…..it would be loaded with my 300 grain, light load (around 1000 mv), wide metplat, cast bullets!
So, get your 454, and enjoy the Hell out of it with loads that are very effective but not brutal to the shooter!
memtb