I've shot prairie dogs for nearly fifty years, and used a variety of center fire rifles and pistols. However, the past couple years I've switched to rimfire rifles with a much higher fun factor. I currently shoot 22lr, 22 mag, 17 hmr, & 17 wsm, all with threaded barrels. I use a rimfire suppressor to help control the noise. As we all know, after a few shots with a 223, the dogs tend to disappear. With the right combination of gun, scope and ammo you can shoot rather consistently out to rather lengthy distances with these calibers. So far this summer, I've shot about 2000 prairie dogs and a couple badgers. Rimfire is cheaper to begin with and you don't have to reload. So, the next time you head out to your favorite dog town, grab that rimfire.