Harmonics definitely apply in 22lr. Why else would people use barrel tuners? I see a massive shift in poi when shooting stingers, about 2" low and to the side. That's harmonics doing their thing. Any weight on the barrel will change the harmonics.
My son shot a deer this year at almost 50 yards (I forgot to tell him how far he could shoot). The bow was sighted for 25 ish yards, so there was a good foot of drop yhat he didn't account for. I watched feom the house as the deer came in and then it turned broadside and I knew he would take...
Let's break it down.
At 33 yards:
It takes the arrow .2 seconds to cover 100 ft at 500 fps. The first sound the deer hears is the string gate slamming down under ~200 lbs of force. That's the loudest thing on the bow, and it happens before the arrow even moves. The deer hears that sound at...
I was simply making an example of energy and velocity. I did say speed, but meant energy. A good portion of energy is lost in the first several hundred yards. If a given bullet loses too much, it may not perform as desired beyond that range.
Even at 500 fps, a deer can dodge the arrow if alert past 30-35 yards. Faster is great at increasing sales, but I've heard of many poor shots because the deer reacted at 40-60+ yards.
Bullets slow down faster when they are going faster. Most of your speed drops off in the first 200-300 yards. Look at an energy graph and you'll see exactly what I mean. You can have a bazillion ft lbs at the muzzle, but it drops like a rock from there out. Energy is dependent on speed...