I am waiting that bullet manufacturers will start making non-lead bullets in weight intervals 205-220 grains to get more speed.
Lead cores that already exists are fine in 250 grains and up.
My shooting range is a bit limited to only 100. So I sight in 2" high at 100. It goes pretty well at 200 and can stretch it to 250 without any problems. And that distance is
almost always ok when harvesting from deer and up.